SLC1A3

Across TCGA patient cohorts, SLC1A3 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC1A3-associated genes across cancer lineages are JNK_pT183_Y185, MIG-6, and Cyclin-B1. Each is linked with SLC1A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC1A3-to-partner and partner-to-SLC1A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by SLC1A3-low versus SLC1A3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC1A3→partner) and Y-score (partner→SLC1A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.165	-2.321	.015	.033	3	2
UCEC	MIG-6 →	+0.101	+1.920	.011	.009	3	2
UCEC	Cyclin-B1 →	+0.598	+3.321	.008	.010	3	2
UCEC	JNK2 →	+0.304	+2.415	<.001	.003	3	1
UCEC	MEK1 →	+0.327	+2.321	.026	.033	3	1
UCEC	mTOR_pS2448 →	-0.170	-2.571	.004	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

JNK_pT183_Y185 by SLC1A3 expression — UCEC

Explore this box plot interactively →