SLC1A1

Across TCGA pan-cancer cohorts, SLC1A1 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SLC1A1 data layer compared with 27 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher SLC1A1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SLC1A1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

BRCA, UCEC, and ACC are the cancer types where SLC1A1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.027	0.963	<.001	36	view →
UCEC	DFS	Median	II,III,IV	1.000	0.438	.013	24	view →
ACC	OS	Median	All	0.158	0.632	.012	9	view →
SKCM	DFS	Median	III,IV	0.812	0.225	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SLC1A1–BRCA (OS)

Open the BRCA breakdown →