SLC1A1

Across TCGA pan-cancer cohorts, SLC1A1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SLC1A1 data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SLC1A1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SLC1A1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

LUAD, CCRCC, and GBM are the cancer types where SLC1A1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	III,IV	0.272	0.805	.002	12	view →
CCRCC	DFS	Median	All	0.968	0.865	.010	4	view →
GBM	DFS	Median	All	0.442	0.303	.034	3	view →
LSCC	OS	Median	II,III,IV	0.902	1.000	.024	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SLC1A1–LUAD (DFS)

Open the LUAD breakdown →