SLC1A1

Across TCGA patient cohorts, SLC1A1 mutation is significantly associated with the RNA expression of many other genes, with 1,904 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC1A1-associated genes across cancer lineages are DEFB122, LINC01941, and RNU7-26P. Each is linked with SLC1A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC1A1-to-partner and partner-to-SLC1A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB122 grouped by SLC1A1-low versus SLC1A1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC1A1→partner) and Y-score (partner→SLC1A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DEFB122 →	+0.158	+4.554	<.001	.009	3	2
LUAD	LINC01941 →	+0.272	+5.742	<.001	<.001	3	2
READ	RNU7-26P →	+0.840	+6.257	<.001	.001	3	2
UCEC	DHRS13 →	+0.656	+2.535	.001	<.001	3	2
SKCM	TLE6 →	+0.700	+3.353	.005	.005	3	2
SKCM	MIR5684 →	+0.439	+2.714	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,904 associations by consensus.

DEFB122 by SLC1A1 expression — LUAD

Explore this box plot interactively →