SLC1A1

Across TCGA patient cohorts, SLC1A1 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC1A1-associated genes across cancer lineages are MEK1, Shc_pY317, and ASNS. Each is linked with SLC1A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC1A1-to-partner and partner-to-SLC1A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by SLC1A1-low versus SLC1A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC1A1→partner) and Y-score (partner→SLC1A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.379	+2.700	.008	.006	3	2
UCEC	Shc_pY317 →	-0.186	-2.000	.001	.010	3	2
UCEC	ASNS →	+0.359	+1.874	.011	.049	3	2
SKCM	PRAS40_pT246 →	-0.178	-3.000	.049	.036	3	1
UCEC	EGFR_pY1068 →	-0.241	-2.000	.014	.030	3	1
UCEC	ERK2 →	+0.172	+3.321	.023	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

MEK1 by SLC1A1 expression — UCEC

Explore this box plot interactively →