SLC1A1

Across TCGA cell cohorts, SLC1A1 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. CNS shows the largest number of these associations.

The most reproducible SLC1A1-associated genes across cancer lineages are HIGD1C, IL3, and RGS21. Each is linked with SLC1A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC1A1-to-partner and partner-to-SLC1A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HIGD1C grouped by SLC1A1-low versus SLC1A1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC1A1→partner) and Y-score (partner→SLC1A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HIGD1C →	+0.064	+5.201	.004	.006	3	1
CNS	IL3 →	+0.045	+4.981	<.001	.008	3	1
CNS	RGS21 →	+0.012	+4.981	<.001	.008	3	1
LARGE_INTESTINE	MCHR2 →	+0.021	+3.684	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

HIGD1C by SLC1A1 expression — BLOOD_Leukemia

Explore this box plot interactively →