SLC1A1

Across TCGA cell cohorts, SLC1A1 mutation is significantly associated with the mutation status of many other genes, with 733 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC1A1-associated genes across cancer lineages are KAT14, HNRNPCL1, and VCAN. Each is linked with SLC1A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC1A1-to-partner and partner-to-SLC1A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KAT14 grouped by SLC1A1-low versus SLC1A1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC1A1→partner) and Y-score (partner→SLC1A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	KAT14 →	+5.044	+5.614	.003	.003	1	2
CNS	HNRNPCL1 →	+6.044	+6.044	.001	.001	1	2
LARGE_INTESTINE	VCAN →	+1.478	+3.408	.007	.007	1	2
LARGE_INTESTINE	TRIT1 →	+4.799	+3.672	.002	.002	1	2
BLOOD_Leukemia	ZNF827 →	+4.309	+4.560	.007	.007	1	2
BLOOD_Leukemia	PLEKHA2 →	+4.309	+4.560	.007	.007	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 733 associations by consensus.

KAT14 by SLC1A1 expression — CNS

Explore this box plot interactively →