SLC19A1

Across TCGA pan-cancer cohorts, SLC19A1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SLC19A1 data layer compared with 28 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SLC19A1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SLC19A1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and HNSC show a favorable association.

LSCC, HNSC, and LUAD are the cancer types where SLC19A1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	III,IV	0.921	0.491	.006	9	view →
HNSC	DFS	Tertile	All	0.828	0.389	.020	4	view →
LUAD	OS	Median	All	0.932	0.647	.032	4	view →
UCEC	DFS	Tertile	All	0.767	0.949	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SLC19A1–LSCC (OS)

Open the LSCC breakdown →