SLC19A1

Across TCGA patient cohorts, SLC19A1 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC19A1-associated genes across cancer lineages are Src_pY416, Src_pY527, and ERK2. Each is linked with SLC19A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC19A1-to-partner and partner-to-SLC19A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Src_pY416 grouped by SLC19A1-low versus SLC19A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC19A1→partner) and Y-score (partner→SLC19A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Src_pY416 →	+0.253	+1.901	.005	.028	3	2
UCEC	Src_pY527 →	+0.422	+1.710	.009	.025	3	2
UCEC	ERK2 →	+0.192	+3.459	.008	.005	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.446	+2.125	.005	.010	3	1
UCEC	Heregulin →	-0.127	-2.169	.006	.003	3	1
UCEC	JNK2 →	+0.279	+1.415	<.001	.046	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Src_pY416 by SLC19A1 expression — UCEC

Explore this box plot interactively →