SLC18B1

Across TCGA pan-cancer cohorts, SLC18B1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SLC18B1 data layer compared with 22 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher SLC18B1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SLC18B1 expression acts as an unfavorable survival marker, although some lineages such as GBM and LSCC show a favorable association.

COAD, OV, and UCEC are the cancer types where SLC18B1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.601	1.000	.014	12	view →
OV	DFS	Median	All	0.646	0.923	.043	4	view →
UCEC	DFS	Median	II,III,IV	0.179	0.800	.038	4	view →
GBM	OS	Quartile	All	0.801	0.265	.025	4	view →
LSCC	OS	Quartile	II,III,IV	0.867	0.420	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SLC18B1–COAD (DFS)

Open the COAD breakdown →