SLC18B1

Across TCGA patient cohorts, SLC18B1 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC18B1-associated genes across cancer lineages are FoxM1, Rab25, and EGFR_pY1068. Each is linked with SLC18B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC18B1-to-partner and partner-to-SLC18B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by SLC18B1-low versus SLC18B1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC18B1→partner) and Y-score (partner→SLC18B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	FoxM1 →	+0.384	+3.009	.009	.019	3	2
UCEC	Rab25 →	-0.489	-3.169	.003	.019	3	2
UCEC	EGFR_pY1068 →	-0.272	-2.321	.031	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.213	-3.000	.012	.036	3	1
UCEC	JNK2 →	+0.232	+2.321	.020	.035	3	1
UCEC	PDCD4 →	-0.689	-3.459	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

FoxM1 by SLC18B1 expression — LUSC

Explore this box plot interactively →