SLC18A2

Across TCGA cell cohorts, SLC18A2 mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SLC18A2-associated genes across cancer lineages are C6orf118, DEFA4, and GPR171. Each is linked with SLC18A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC18A2-to-partner and partner-to-SLC18A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C6orf118 grouped by SLC18A2-low versus SLC18A2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC18A2→partner) and Y-score (partner→SLC18A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C6orf118 →	+0.160	+4.115	<.001	.001	3	1
LARGE_INTESTINE	DEFA4 →	+0.026	+4.022	<.001	.006	3	1
LARGE_INTESTINE	GPR171 →	+0.017	+3.688	<.001	.002	3	1
LARGE_INTESTINE	OR4A47 →	+0.015	+4.022	<.001	.006	3	1
LARGE_INTESTINE	OR6Q1 →	+0.015	+4.022	<.001	.006	3	1
BLOOD_Leukemia	GZMK →	+0.427	+3.359	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

C6orf118 by SLC18A2 expression — LARGE_INTESTINE

Explore this box plot interactively →