SLC18A2

Across TCGA cell cohorts, SLC18A2 mutation is significantly associated with the mutation status of many other genes, with 4,040 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC18A2-associated genes across cancer lineages are FAT2, PI4KA, and SPTBN2. Each is linked with SLC18A2 in more than 5 cancer types. Because this analysis shows association rather than direction, both SLC18A2-to-partner and partner-to-SLC18A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAT2 grouped by SLC18A2-low versus SLC18A2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC18A2→partner) and Y-score (partner→SLC18A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	FAT2 →	+2.053	+3.233	.004	.004	1	6
CNS	PI4KA →	+4.459	+5.277	.005	.005	1	5
UPPER_AERODIGESTIVE_TRACT	SPTBN2 →	+5.392	+5.392	.004	.004	1	5
CNS	CMIP →	+5.044	+5.614	.003	.003	1	5
LARGE_INTESTINE	PRRC2C →	+1.559	+3.630	.002	.002	1	5
LARGE_INTESTINE	KALRN →	+1.900	+3.991	<.001	<.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,040 associations by consensus.

FAT2 by SLC18A2 expression — BLOOD_Lymphoma

Explore this box plot interactively →