SLC18A1

Across TCGA patient cohorts, SLC18A1 mutation is significantly associated with the RNA expression of many other genes, with 4,824 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC18A1-associated genes across cancer lineages are FBXO5, NUSAP1, and KNL1. Each is linked with SLC18A1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SLC18A1-to-partner and partner-to-SLC18A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FBXO5 grouped by SLC18A1-low versus SLC18A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC18A1→partner) and Y-score (partner→SLC18A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FBXO5 →	+0.641	+2.321	.001	.001	3	4
UCEC	NUSAP1 →	+0.758	+2.807	<.001	<.001	3	4
UCEC	KNL1 →	+0.758	+3.949	<.001	<.001	3	4
COAD	MPHOSPH9 →	+0.572	+3.486	<.001	.002	3	4
UCEC	ARHGAP11A →	+0.744	+3.906	<.001	<.001	3	4
UCEC	CKAP2L →	+0.711	+3.931	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,824 associations by consensus.

FBXO5 by SLC18A1 expression — UCEC

Explore this box plot interactively →