SLC17A8

Across TCGA patient cohorts, SLC17A8 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC17A8-associated genes across cancer lineages are Bcl-xL, MEK1, and ASNS. Each is linked with SLC17A8 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC17A8-to-partner and partner-to-SLC17A8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bcl-xL grouped by SLC17A8-low versus SLC17A8-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC17A8→partner) and Y-score (partner→SLC17A8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	Bcl-xL →	-0.128	-1.493	.012	.028	3	2
UCEC	MEK1 →	+0.560	+3.247	<.001	<.001	3	2
UCEC	ASNS →	+0.391	+2.459	.004	.019	3	2
UCEC	ATM →	-0.634	-2.446	<.001	.018	3	2
UCEC	CD49b →	-0.236	-2.308	.030	.033	3	2
UCEC	Cyclin-B1 →	+0.618	+3.584	.004	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Bcl-xL by SLC17A8 expression — LUSC

Explore this box plot interactively →