SLC17A8

Across TCGA cell cohorts, SLC17A8 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC17A8-associated genes across cancer lineages are AMY1A, RBMY1E, and PPP1R3A. Each is linked with SLC17A8 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC17A8-to-partner and partner-to-SLC17A8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AMY1A grouped by SLC17A8-low versus SLC17A8-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC17A8→partner) and Y-score (partner→SLC17A8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	AMY1A →	+0.246	+3.256	.001	.005	3	2
LUNG_NSCLC_LUSC	RBMY1E →	+0.820	+4.643	.002	.008	3	1
SKIN	PPP1R3A →	+0.034	+3.345	<.001	.001	3	1
SKIN	C4orf50 →	+0.015	+3.099	<.001	.002	3	1
SKIN	SMLR1 →	+0.021	+3.807	.003	.006	3	1
LARGE_INTESTINE	MMP26 →	+0.033	+3.217	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

AMY1A by SLC17A8 expression — LUNG_SCLC

Explore this box plot interactively →