SLC17A7

Across TCGA patient cohorts, SLC17A7 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC17A7-associated genes across cancer lineages are IGFBP2, MSH6, and C-Raf. Each is linked with SLC17A7 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC17A7-to-partner and partner-to-SLC17A7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFBP2 grouped by SLC17A7-low versus SLC17A7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC17A7→partner) and Y-score (partner→SLC17A7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGFBP2 →	-0.628	-2.584	.008	.010	3	2
UCEC	MSH6 →	-0.465	-1.847	<.001	.008	3	2
SKCM	C-Raf →	+0.194	+2.824	.015	.034	3	2
COAD	LKB1 →	+0.104	+2.824	.032	.034	3	1
UCEC	eIF4E →	+0.157	+2.115	.043	.017	3	1
UCEC	ERK2 →	+0.167	+1.847	.018	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

IGFBP2 by SLC17A7 expression — UCEC

Explore this box plot interactively →