SLC17A5

Across TCGA patient cohorts, SLC17A5 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC17A5-associated genes across cancer lineages are JNK2, p27_pT198, and Shc_pY317. Each is linked with SLC17A5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC17A5-to-partner and partner-to-SLC17A5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by SLC17A5-low versus SLC17A5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC17A5→partner) and Y-score (partner→SLC17A5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.208	+2.321	.037	.035	3	1
UCEC	p27_pT198 →	+0.110	+2.321	.041	.035	3	1
UCEC	Shc_pY317 →	-0.167	-2.321	.028	.035	3	1
UCEC	STAT3_pY705 →	-0.452	-3.459	<.001	.005	3	1
UCEC	C-Raf →	+0.190	+3.000	.008	.036	3	1
UCEC	INPP4B →	-0.388	-2.308	.017	.036	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

JNK2 by SLC17A5 expression — UCEC

Explore this box plot interactively →