SLC17A4

Across TCGA pan-cancer cohorts, SLC17A4 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SLC17A4 data layer compared with 18 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SLC17A4 Mutation is associated with better overall survival. In most high-consensus cancer types, elevated SLC17A4 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, ESCA, and LUSC are the cancer types where SLC17A4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	1.000	0.648	.006	30	view →
ESCA	DFS	Median	All	0.169	0.538	.003	12	view →
LUSC	DFS	Median	All	0.181	0.796	<.001	9	view →
SKCM	DFS	Median	All	0.100	0.215	.008	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SLC17A4–UCEC (OS)

Open the UCEC breakdown →