SLC17A4

Across TCGA patient cohorts, SLC17A4 mutation is significantly associated with the RNA expression of many other genes, with 2,673 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC17A4-associated genes across cancer lineages are SPC24, TEDC2, and TYMS. Each is linked with SLC17A4 in more than 3 cancer types. Because this analysis shows association rather than direction, both SLC17A4-to-partner and partner-to-SLC17A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPC24 grouped by SLC17A4-low versus SLC17A4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC17A4→partner) and Y-score (partner→SLC17A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SPC24 →	+0.548	+2.807	.003	<.001	3	4
UCEC	TEDC2 →	+0.496	+2.136	.001	<.001	3	4
LUAD	TYMS →	+0.863	+3.216	<.001	.009	3	4
UCEC	METTL5 →	+0.324	+2.296	.003	<.001	3	4
UCEC	PANO1 →	+0.376	+2.178	<.001	.009	3	3
UCEC	TIMM8B →	+0.412	+2.115	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,673 associations by consensus.

SPC24 by SLC17A4 expression — UCEC

Explore this box plot interactively →