SLC17A4

Across TCGA patient cohorts, SLC17A4 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC17A4-associated genes across cancer lineages are Cyclin-B1, GAPDH, and p62 Lck ligand. Each is linked with SLC17A4 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC17A4-to-partner and partner-to-SLC17A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by SLC17A4-low versus SLC17A4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC17A4→partner) and Y-score (partner→SLC17A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.721	+3.700	<.001	.001	3	3
UCEC	GAPDH →	+0.503	+3.807	.006	<.001	3	3
UCEC	p62 Lck ligand →	+0.487	+2.459	<.001	<.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.827	+2.999	<.001	<.001	3	3
LUAD	p70-S6K →	+0.245	+2.321	.005	.033	3	2
LUAD	p90 RSK_pT359_S363 →	-0.175	-3.169	.008	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

Cyclin-B1 by SLC17A4 expression — UCEC

Explore this box plot interactively →