SLC17A3

Across TCGA patient cohorts, SLC17A3 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC17A3-associated genes across cancer lineages are PRDX1, Annexin_VII, and Bim. Each is linked with SLC17A3 in more than 3 cancer types. Because this analysis shows association rather than direction, both SLC17A3-to-partner and partner-to-SLC17A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRDX1 grouped by SLC17A3-low versus SLC17A3-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC17A3→partner) and Y-score (partner→SLC17A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PRDX1 →	+0.417	+2.321	<.001	.035	3	4
LUAD	Annexin_VII →	-0.110	-2.305	.048	.035	3	2
SKCM	Bim →	-0.288	-2.321	.008	.006	3	2
UCEC	JNK2 →	+0.179	+1.523	.004	.008	3	2
UCEC	mTOR_pS2448 →	-0.102	-1.571	.032	.032	3	2
UCEC	TIGAR →	+0.169	+1.847	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

PRDX1 by SLC17A3 expression — LUAD

Explore this box plot interactively →