SLC16A8

Across TCGA pan-cancer cohorts, SLC16A8 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SLC16A8 data layer compared with 4 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher SLC16A8 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SLC16A8 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BLCA show a favorable association.

UVM, HNSC, and BLCA are the cancer types where SLC16A8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.424	0.737	<.001	154	view →
HNSC	DFS	Median	II,III,IV	0.750	0.617	<.001	112	view →
BLCA	OS	Tertile	All	0.725	0.535	<.001	101	view →
COAD	DFS	Tertile	All	0.366	0.624	.002	81	view →
KIRC	DFS	Median	II,III,IV	0.417	0.614	<.001	80	view →
CHOL	DFS	Quartile	II,III,IV	0.114	0.706	.006	52	view →
SKCM	DFS	Tertile	All	0.662	0.500	.002	37	view →
STAD	OS	Quartile	III,IV	0.726	0.295	.001	24	view →
ACC	DFS	Quartile	All	0.262	0.629	.020	23	view →
CESC	OS	Median	IV	0.780	0.401	.030	20	view →
PRAD	DFS	Median	All	0.712	0.802	.002	20	view →
READ	DFS	Tertile	IV	0.368	0.767	.024	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

SLC16A8–UVM (DFS)

Open the UVM breakdown →