SLC16A6

Across TCGA patient cohorts, SLC16A6 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC16A6-associated genes across cancer lineages are MEK1, STAT3_pY705, and Chk2_pT68. Each is linked with SLC16A6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC16A6-to-partner and partner-to-SLC16A6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by SLC16A6-low versus SLC16A6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC16A6→partner) and Y-score (partner→SLC16A6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.486	+2.807	<.001	.003	3	2
UCEC	STAT3_pY705 →	-0.420	-2.000	<.001	.029	3	2
UCEC	Chk2_pT68 →	-0.157	-2.312	.036	.034	3	2
UCEC	4E-BP1 →	+0.318	+3.029	.003	.018	3	2
COAD	HER3 →	+0.475	+2.815	.019	.036	3	2
UCEC	GAPDH →	+0.540	+3.169	.012	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

MEK1 by SLC16A6 expression — UCEC

Explore this box plot interactively →