SLC16A5

Across TCGA pan-cancer cohorts, SLC16A5 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated SLC16A5 data layer compared with 4 for mutation status.

The strongest signal is observed in brain lower grade glioma (LGG), where higher SLC16A5 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SLC16A5 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCS show a favorable association.

LGG, HNSC, and PAAD are the cancer types where SLC16A5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.307	0.481	<.001	51	view →
HNSC	OS	Median	IV	0.492	0.287	.001	40	view →
PAAD	DFS	Quartile	All	0.169	0.482	<.001	34	view →
COAD	DFS	Median	II,III,IV	0.698	0.812	.002	33	view →
UCS	DFS	Tertile	IV	0.861	0.275	.024	24	view →
SKCM	DFS	Tertile	III,IV	0.353	0.666	.006	17	view →
KIRP	DFS	Quartile	II,III,IV	0.125	0.745	.003	14	view →
ACC	OS	Tertile	III,IV	0.218	0.772	.013	14	view →
SCLC	DFS	Median	III,IV	0.685	0.379	.012	10	view →
CESC	OS	Median	III,IV	0.762	0.530	.036	10	view →
ESCA	OS	Median	All	0.647	1.000	.015	9	view →
BRCA	OS	Quartile	III,IV	0.902	0.734	.012	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

SLC16A5–LGG (DFS)

Open the LGG breakdown →