SLC16A4

Across TCGA patient cohorts, SLC16A4 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC16A4-associated genes across cancer lineages are JNK_pT183_Y185, Notch1, and p62 Lck ligand. Each is linked with SLC16A4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC16A4-to-partner and partner-to-SLC16A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by SLC16A4-low versus SLC16A4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC16A4→partner) and Y-score (partner→SLC16A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.207	-3.446	.014	.005	3	1
UCEC	Notch1 →	+0.193	+2.321	.006	.035	3	1
UCEC	p62 Lck ligand →	+0.370	+3.009	.023	.019	3	1
UCEC	PCNA →	+0.293	+3.000	.006	.036	3	1
UCEC	Rab25 →	-0.555	-2.999	<.001	.035	3	1
UCEC	Src_pY416 →	-0.265	-2.308	.028	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

JNK_pT183_Y185 by SLC16A4 expression — UCEC

Explore this box plot interactively →