SLC16A3

Across TCGA patient cohorts, SLC16A3 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC16A3-associated genes across cancer lineages are ERK2, Ku80, and MAPK_pT202_Y204. Each is linked with SLC16A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC16A3-to-partner and partner-to-SLC16A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by SLC16A3-low versus SLC16A3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC16A3→partner) and Y-score (partner→SLC16A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.225	+3.169	.033	.020	3	1
UCEC	Ku80 →	+0.430	+3.183	<.001	.010	3	1
UCEC	MAPK_pT202_Y204 →	-0.705	-3.169	.006	.020	3	1
UCEC	MEK1_p_S217_S221 →	-0.392	-3.169	.008	.019	3	1
UCEC	Myosin-IIa_pS1943 →	+0.276	+3.183	.014	.010	3	1
UCEC	p62 Lck ligand →	+0.566	+3.179	.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

ERK2 by SLC16A3 expression — UCEC

Explore this box plot interactively →