SLC16A2

Across TCGA patient cohorts, SLC16A2 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC16A2-associated genes across cancer lineages are STAT3_pY705, 14-3-3_beta, and EGFR_pY1068. Each is linked with SLC16A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC16A2-to-partner and partner-to-SLC16A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by SLC16A2-low versus SLC16A2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC16A2→partner) and Y-score (partner→SLC16A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.380	-1.700	<.001	.001	3	2
UCEC	14-3-3_beta →	-0.085	-1.738	.005	.011	3	1
UCEC	EGFR_pY1068 →	-0.161	-1.263	.036	.019	3	1
UCEC	eIF4G →	+0.236	+1.999	.013	.008	3	1
UCEC	A-Raf_pS299 →	-0.120	-1.874	<.001	.002	3	1
UCEC	ERK2 →	+0.143	+1.473	.015	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

STAT3_pY705 by SLC16A2 expression — UCEC

Explore this box plot interactively →