SLC15A4

Across TCGA pan-cancer cohorts, SLC15A4 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SLC15A4 data layer compared with 22 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SLC15A4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SLC15A4 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

PDAC, LUAD, and HNSC are the cancer types where SLC15A4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	II,III,IV	0.191	0.444	<.001	74	view →
LUAD	OS	Median	II,III,IV	0.443	0.788	.003	32	view →
HNSC	OS	Quartile	II,III,IV	1.000	0.904	.009	26	view →
GBM	DFS	Median	All	0.623	0.806	.003	15	view →
UCEC	OS	Median	III,IV	0.494	1.000	.016	12	view →
CCRCC	OS	Median	II,III,IV	0.485	1.000	.010	10	view →
LSCC	DFS	Tertile	II,III,IV	0.569	0.945	.004	9	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SLC15A4–PDAC (DFS)

Open the PDAC breakdown →