SLC15A4

Across TCGA patient cohorts, SLC15A4 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC15A4-associated genes across cancer lineages are mTOR_pS2448, ATM, and eEF2. Each is linked with SLC15A4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC15A4-to-partner and partner-to-SLC15A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by SLC15A4-low versus SLC15A4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC15A4→partner) and Y-score (partner→SLC15A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.165	-2.321	.002	.001	3	2
UCEC	ATM →	-0.461	-1.584	.004	.019	3	2
UCEC	eEF2 →	+0.299	+2.000	.020	.029	3	1
UCEC	EGFR_pY1068 →	-0.301	-1.925	<.001	.005	3	1
UCEC	ERK2 →	+0.191	+1.906	.005	.015	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.478	+2.331	.008	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

mTOR_pS2448 by SLC15A4 expression — UCEC

Explore this box plot interactively →