SLC15A4

Across TCGA cell cohorts, SLC15A4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,032 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC15A4-associated GO terms across cancer lineages are Regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway, Peptidoglycan transport, and Regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway. Each is linked with SLC15A4 in more than 16 cancer types. Because this analysis shows association rather than direction, both SLC15A4-to-partner and partner-to-SLC15A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway grouped by SLC15A4-low versus SLC15A4-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC15A4→partner) and Y-score (partner→SLC15A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway →	+0.892	+0.707	.002	.002	2	17
LARGE_INTESTINE	Peptidoglycan transport →	+1.001	+0.570	<.001	<.001	3	15
OVARY	Regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway →	+0.142	+0.707	.006	.001	3	13
LIVER	L-histidine transmembrane transport →	+0.162	+0.896	.003	.002	3	13
LUNG_NSCLC_LUSC	Oligopeptide import across plasma membrane →	+1.116	+0.846	.001	.002	2	14
LUNG_NSCLC_LUSC	Dipeptide import across plasma membrane →	+1.116	+0.846	.001	.002	2	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,032 associations by consensus.

Regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway by SLC15A4 expression — BONE

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