SLC15A4

Across TCGA cell cohorts, SLC15A4 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SLC15A4-associated genes across cancer lineages are ASPN, DEFA6, and HELT. Each is linked with SLC15A4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC15A4-to-partner and partner-to-SLC15A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASPN grouped by SLC15A4-low versus SLC15A4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC15A4→partner) and Y-score (partner→SLC15A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ASPN →	+0.040	+3.426	.002	.007	3	1
CNS	DEFA6 →	+0.091	+4.981	<.001	.008	3	1
CNS	HELT →	+0.041	+5.321	<.001	.005	3	1
BLOOD_Lymphoma	RAX →	+0.750	+5.247	<.001	.001	3	1
BLOOD_Lymphoma	DAZ1 →	+0.183	+4.191	<.001	.007	3	1
BLOOD_Lymphoma	DAZ2 →	+0.019	+4.643	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

ASPN by SLC15A4 expression — LARGE_INTESTINE

Explore this box plot interactively →