SLC15A2

Across TCGA pan-cancer cohorts, SLC15A2 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated SLC15A2 data layer compared with 17 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher SLC15A2 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SLC15A2 expression acts as an unfavorable survival marker, although some lineages such as SKCM and UCEC show a favorable association.

KICH, THCA, and SKCM are the cancer types where SLC15A2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	All	0.081	0.904	<.001	30	view →
THCA	DFS	Median	All	0.095	0.829	<.001	24	view →
SKCM	OS	Median	II,III,IV	0.947	0.823	.010	11	view →
LGG	DFS	Median	All	0.172	0.845	<.001	9	view →
UCEC	DFS	Median	All	0.970	0.828	.023	8	view →
SARC	DFS	Median	All	0.159	0.613	.015	6	view →
CESC	OS	Median	II,III,IV	0.566	0.829	.045	6	view →
ESCA	DFS	Median	All	0.215	0.537	.022	6	view →
HNSC	OS	Median	All	0.393	0.769	.047	3	view →
GBM	OS	Median	All	0.121	0.415	.042	3	view →
LIHC	DFS	Median	All	0.209	0.556	.049	3	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

SLC15A2–KICH (DFS)

Open the KICH breakdown →