SLC15A1

Across TCGA pan-cancer cohorts, SLC15A1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SLC15A1 data layer compared with 21 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher SLC15A1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SLC15A1 expression acts as an unfavorable survival marker.

OV, PAAD, and LGG are the cancer types where SLC15A1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	DFS	Median	II,III,IV	0.220	0.541	.032	18	view →
PAAD	DFS	Median	All	0.100	0.484	.003	12	view →
LGG	DFS	Median	All	0.118	0.832	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
PRAD	DFS	Median	All	0.150	0.774	.003	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SLC15A1–OV (DFS)

Open the OV breakdown →