SLC14A1

Across TCGA patient cohorts, SLC14A1 mutation is significantly associated with the RNA expression of many other genes, with 2,301 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible SLC14A1-associated genes across cancer lineages are CDC45, MIR4418, and SKA2. Each is linked with SLC14A1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SLC14A1-to-partner and partner-to-SLC14A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDC45 grouped by SLC14A1-low versus SLC14A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC14A1→partner) and Y-score (partner→SLC14A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDC45 →	+0.692	+3.923	<.001	<.001	3	4
HNSC	MIR4418 →	+0.612	+4.822	<.001	.006	3	3
UCEC	SKA2 →	+0.589	+2.010	.001	.001	3	3
UCEC	CDCA2 →	+0.740	+3.721	<.001	<.001	3	3
SKCM	FAM72B →	+0.557	+3.897	<.001	<.001	3	3
SKCM	ARHGAP11A →	+0.920	+2.424	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,301 associations by consensus.

CDC45 by SLC14A1 expression — UCEC

Explore this box plot interactively →