SLC14A1

Across TCGA cell cohorts, SLC14A1 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC14A1-associated genes across cancer lineages are KIR2DL3, PRAMEF20, and TECRL. Each is linked with SLC14A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC14A1-to-partner and partner-to-SLC14A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KIR2DL3 grouped by SLC14A1-low versus SLC14A1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC14A1→partner) and Y-score (partner→SLC14A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	KIR2DL3 →	+0.025	+4.981	<.001	.008	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.012	+4.437	<.001	.004	3	1
LARGE_INTESTINE	TECRL →	+0.017	+4.562	<.001	<.001	3	1
LARGE_INTESTINE	OR5V1 →	+0.008	+4.437	<.001	.004	3	1
SKIN	C2CD4B →	+0.041	+4.684	<.001	.002	3	1
BLOOD_Lymphoma	OR2AP1 →	+0.025	+4.867	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

KIR2DL3 by SLC14A1 expression — CNS

Explore this box plot interactively →