SLC13A3

Across TCGA patient cohorts, SLC13A3 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC13A3-associated genes across cancer lineages are ER-alpha_pS118, ERK2, and Notch1. Each is linked with SLC13A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC13A3-to-partner and partner-to-SLC13A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ER-alpha_pS118 grouped by SLC13A3-low versus SLC13A3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC13A3→partner) and Y-score (partner→SLC13A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ER-alpha_pS118 →	-0.339	-2.584	.011	.010	3	2
UCEC	ERK2 →	+0.203	+1.765	.004	.014	3	2
UCEC	Notch1 →	+0.126	+2.469	.017	.010	3	2
UCEC	p62 Lck ligand →	+0.247	+1.594	.043	.042	3	2
UCEC	PDCD4 →	-0.524	-2.321	.002	.033	3	2
UCEC	Shc_pY317 →	-0.191	-2.700	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

ER-alpha_pS118 by SLC13A3 expression — UCEC

Explore this box plot interactively →