Across TCGA pan-cancer cohorts, SLC12A8 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SLC12A8 data layer compared with 31 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SLC12A8 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SLC12A8 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

CCRCC, HNSC, and LUAD are the cancer types where SLC12A8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.407	0.875	.021	8	view →
HNSC	OS	Median	III,IV	0.806	0.435	.038	6	view →
LUAD	DFS	Tertile	All	0.849	1.000	.028	3	view →
LSCC	DFS	Median	II,III,IV	0.381	1.000	.008	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: SLC12A8 tumor-vs-normal RNA expression · all SLC12A8 data types