SLC12A8

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, SLC12A8 mutation is significantly associated with the RNA expression of many other genes, with 1,497 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC12A8-associated genes across cancer lineages are ZNF479, MED27, and PMPCA. Each is linked with SLC12A8 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC12A8-to-partner and partner-to-SLC12A8 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC12A8→partner) and Y-score (partner→SLC12A8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
SCLCZNF479 →+0.178+5.189<.001.00632
UCECMED27 →+0.327+3.406.007.00432
UCECPMPCA →+0.353+2.354.003<.00132
UCECENTR1 →+0.345+2.238.006.00632
UCECDOLPP1 →+0.499+2.831.001.00132
UCECHDGFL2 →+0.365+2.828.007.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 1,497 associations by consensus.

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