Across TCGA patient cohorts, SLC12A8 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible SLC12A8-associated genes across cancer lineages are c-Met_pY1235, VHL, and Caspase-7-cleavedD198. Each is linked with SLC12A8 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC12A8-to-partner and partner-to-SLC12A8 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC12A8→partner) and Y-score (partner→SLC12A8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Met_pY1235 →	+0.097	+2.817	.001	.001	3	3
UCEC	VHL →	-0.928	-2.000	<.001	.030	3	2
UCEC	Caspase-7-cleavedD198 →	+0.720	+1.894	.003	.030	3	2
UCEC	Caspase-8 →	-0.241	-3.432	.020	.005	3	2
UCEC	4E-BP1 →	+0.334	+3.351	.002	.005	3	2
UCEC	C-Raf →	+0.165	+3.169	.005	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Exploration

SLC12A8 survival (RNA) · tumor vs normal (RNA) · all SLC12A8 data types