SLC12A7

Across TCGA patient cohorts, SLC12A7 mutation is significantly associated with the RNA expression of many other genes, with 2,645 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC12A7-associated genes across cancer lineages are CSN3, TNNC2, and NEURL2. Each is linked with SLC12A7 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC12A7-to-partner and partner-to-SLC12A7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CSN3 grouped by SLC12A7-low versus SLC12A7-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC12A7→partner) and Y-score (partner→SLC12A7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	CSN3 →	+0.978	+3.809	<.001	.009	3	3
STAD	TNNC2 →	-1.153	-3.321	.004	.009	3	3
STAD	NEURL2 →	-0.446	-3.568	.008	.002	3	3
UCEC	GSR →	+0.636	+2.606	<.001	<.001	3	3
UCEC	NDUFC1 →	+0.319	+2.042	.001	.004	3	3
UCEC	COMMD9 →	+0.246	+1.922	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,645 associations by consensus.

CSN3 by SLC12A7 expression — LIHC

Explore this box plot interactively →