SLC12A7

Across TCGA patient cohorts, SLC12A7 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC12A7-associated genes across cancer lineages are Cyclin-B1, Caspase-7-cleavedD198, and TFRC. Each is linked with SLC12A7 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC12A7-to-partner and partner-to-SLC12A7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by SLC12A7-low versus SLC12A7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC12A7→partner) and Y-score (partner→SLC12A7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.609	+3.807	<.001	<.001	3	3
COAD	Caspase-7-cleavedD198 →	+1.118	+3.338	<.001	.004	3	3
UCEC	TFRC →	+0.420	+2.459	.016	.018	3	3
UCEC	p21 →	+0.174	+1.652	.006	.006	3	2
UCEC	PCNA →	+0.246	+2.087	<.001	.005	3	2
UCEC	STAT3_pY705 →	-0.272	-1.392	.001	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

Cyclin-B1 by SLC12A7 expression — UCEC

Explore this box plot interactively →