SLC12A6

Across TCGA patient cohorts, SLC12A6 mutation is significantly associated with the RNA expression of many other genes, with 4,519 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC12A6-associated genes across cancer lineages are ZFYVE19, SNRPD1, and POP7. Each is linked with SLC12A6 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC12A6-to-partner and partner-to-SLC12A6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZFYVE19 grouped by SLC12A6-low versus SLC12A6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC12A6→partner) and Y-score (partner→SLC12A6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZFYVE19 →	+0.308	+2.091	.001	<.001	3	3
UCEC	SNRPD1 →	+0.406	+2.180	<.001	<.001	3	3
UCEC	POP7 →	+0.230	+2.475	.005	<.001	3	3
UCEC	TXNL1 →	+0.331	+1.765	<.001	<.001	3	3
UCEC	WDR76 →	+0.746	+2.684	<.001	<.001	3	3
UCEC	SNRPD3 →	+0.389	+2.662	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,519 associations by consensus.

ZFYVE19 by SLC12A6 expression — UCEC

Explore this box plot interactively →