SLC12A6

Across TCGA patient cohorts, SLC12A6 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC12A6-associated genes across cancer lineages are Shc_pY317, eIF4E, and ERK2. Each is linked with SLC12A6 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC12A6-to-partner and partner-to-SLC12A6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by SLC12A6-low versus SLC12A6-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC12A6→partner) and Y-score (partner→SLC12A6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Shc_pY317 →	-0.219	-3.161	.007	.019	3	2
UCEC	eIF4E →	+0.180	+2.321	.004	<.001	3	2
UCEC	ERK2 →	+0.150	+1.530	.009	.004	3	2
UCEC	ACVRL1 →	-0.090	-1.571	.028	.032	3	2
UCEC	MEK1 →	+0.435	+2.273	<.001	<.001	3	2
UCEC	Notch1 →	+0.146	+2.100	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

Shc_pY317 by SLC12A6 expression — COAD

Explore this box plot interactively →