SLC12A6

Across TCGA cell cohorts, SLC12A6 mutation is significantly associated with the RNA expression of many other genes, with 367 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC12A6-associated genes across cancer lineages are REG1B, C9orf72, and MIS12. Each is linked with SLC12A6 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC12A6-to-partner and partner-to-SLC12A6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REG1B grouped by SLC12A6-low versus SLC12A6-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC12A6→partner) and Y-score (partner→SLC12A6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	REG1B →	+1.039	+5.169	<.001	.005	3	3
LARGE_INTESTINE	C9orf72 →	+0.697	+2.502	.003	.005	3	2
LARGE_INTESTINE	MIS12 →	+0.522	+2.588	.005	.004	3	2
BLOOD_Lymphoma	KRTAP4-11 →	+0.035	+5.209	<.001	.005	3	2
SKIN	OPN4 →	+0.033	+4.273	.001	.006	3	1
SKIN	DNMT3L →	+0.052	+4.273	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 367 associations by consensus.

REG1B by SLC12A6 expression — BREAST

Explore this box plot interactively →