SLC12A5

Across TCGA patient cohorts, SLC12A5 mutation is significantly associated with the RNA expression of many other genes, with 5,875 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC12A5-associated genes across cancer lineages are DDT, POLE2, and NDUFA9. Each is linked with SLC12A5 in more than 5 cancer types. Because this analysis shows association rather than direction, both SLC12A5-to-partner and partner-to-SLC12A5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DDT grouped by SLC12A5-low versus SLC12A5-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC12A5→partner) and Y-score (partner→SLC12A5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	DDT →	+0.353	+1.648	<.001	.004	3	6
UCEC	POLE2 →	+0.408	+1.606	<.001	.001	3	5
STAD	NDUFA9 →	+0.467	+3.268	<.001	.008	3	5
UCEC	BCCIP →	+0.388	+2.485	<.001	<.001	3	5
UCEC	CCDC51 →	+0.296	+2.066	.006	<.001	3	4
UCEC	CHAF1A →	+0.531	+1.536	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,875 associations by consensus.

DDT by SLC12A5 expression — SKCM

Explore this box plot interactively →