SLC12A5

Across TCGA patient cohorts, SLC12A5 mutation is significantly associated with the total protein of many other genes, with 69 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC12A5-associated genes across cancer lineages are Caspase-7-cleavedD198, P-Cadherin, and Annexin_VII. Each is linked with SLC12A5 in more than 3 cancer types. Because this analysis shows association rather than direction, both SLC12A5-to-partner and partner-to-SLC12A5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by SLC12A5-low versus SLC12A5-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC12A5→partner) and Y-score (partner→SLC12A5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+0.980	+2.476	<.001	.009	3	4
LUAD	P-Cadherin →	+0.207	+1.891	.025	.030	3	3
LUSC	Annexin_VII →	+0.104	+3.169	.027	.018	3	3
SKCM	PCNA →	+0.179	+2.906	.002	.001	3	3
STAD	ASNS →	+0.759	+3.169	<.001	.017	3	3
UCEC	C-Raf →	+0.078	+1.253	.046	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

Caspase-7-cleavedD198 by SLC12A5 expression — COAD

Explore this box plot interactively →