SLC12A3

Across TCGA patient cohorts, SLC12A3 mutation is significantly associated with the RNA expression of many other genes, with 4,719 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC12A3-associated genes across cancer lineages are CDCA8, PPP2R2D, and MIR4452. Each is linked with SLC12A3 in more than 3 cancer types. Because this analysis shows association rather than direction, both SLC12A3-to-partner and partner-to-SLC12A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDCA8 grouped by SLC12A3-low versus SLC12A3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC12A3→partner) and Y-score (partner→SLC12A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDCA8 →	+0.609	+1.595	<.001	<.001	3	4
UCEC	PPP2R2D →	+0.316	+2.021	<.001	<.001	3	4
CESC	MIR4452 →	+0.225	+3.984	<.001	.009	3	3
COAD	PHF7 →	+0.528	+3.183	<.001	.009	3	3
COAD	EIF2B2 →	+0.379	+3.275	.002	.007	3	3
UCEC	PSMC3IP →	+0.622	+1.794	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,719 associations by consensus.

CDCA8 by SLC12A3 expression — UCEC

Explore this box plot interactively →