SLC12A3

Across TCGA patient cohorts, SLC12A3 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC12A3-associated genes across cancer lineages are INPP4B, Shc_pY317, and ATM. Each is linked with SLC12A3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC12A3-to-partner and partner-to-SLC12A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by SLC12A3-low versus SLC12A3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC12A3→partner) and Y-score (partner→SLC12A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	INPP4B →	-0.147	-2.000	.032	.027	3	3
UCEC	Shc_pY317 →	-0.121	-1.584	.007	.032	3	3
UCEC	ATM →	-0.404	-2.000	.002	.009	3	3
SKCM	NF2 →	+0.294	+1.906	.001	.014	3	2
COAD	GAPDH →	+0.991	+3.012	<.001	.018	2	3
UCEC	TFRC →	+0.461	+1.378	.003	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

INPP4B by SLC12A3 expression — SKCM

Explore this box plot interactively →