SLC12A3

Across TCGA cell cohorts, SLC12A3 mutation is significantly associated with the RNA expression of many other genes, with 154 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC12A3-associated genes across cancer lineages are KRTAP10-2, OPRPN, and THRB. Each is linked with SLC12A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC12A3-to-partner and partner-to-SLC12A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP10-2 grouped by SLC12A3-low versus SLC12A3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC12A3→partner) and Y-score (partner→SLC12A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KRTAP10-2 →	+0.033	+1.894	.002	.009	3	2
LUNG_NSCLC_LUAD	OPRPN →	+0.021	+2.887	<.001	.009	3	2
LARGE_INTESTINE	THRB →	-1.067	-3.392	.001	.001	3	2
LUNG_SCLC	CRYGB →	+0.062	+4.643	<.001	.004	3	1
LUNG_SCLC	C3orf85 →	+0.149	+5.169	<.001	<.001	3	1
SKIN	COX4I2 →	+0.189	+4.273	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 154 associations by consensus.

KRTAP10-2 by SLC12A3 expression — LARGE_INTESTINE

Explore this box plot interactively →